{"symbol":"SFRP1","synonyms":["FRP-1","SARP2","FRZA"],"name":"secreted frizzled-related protein 1","description":"This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":6422,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6422","proteins":[{"symbol":"SFRP1_HUMAN","href":"/api/1.0/protein/SFRP1_HUMAN"}],"hgncRootFamilies":[{"name":"Secreted frizzled-related proteins (SFRP)","href":"/api/1.0/gene_family/Secreted+frizzled-related+proteins+%28SFRP%29"}]}