{"symbol":"SH2B3","synonyms":["LNK"],"name":"SH2B adaptor protein 3","description":"This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":10019,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10019","proteins":[{"symbol":"SH2B3_HUMAN","href":"/api/1.0/protein/SH2B3_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"},{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}