{"symbol":"SHMT1","synonyms":["CSHMT","SHMT"],"name":"serine hydroxymethyltransferase 1 (soluble)","description":"This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]","ncbiEntrezGeneId":6470,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6470","proteins":[{"symbol":"GLYC_HUMAN","href":"/api/1.0/protein/GLYC_HUMAN"}],"hgncRootFamilies":[]}