{"symbol":"SHROOM2","synonyms":["HSAPXL","APXL"],"name":"shroom family member 2","description":"This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":357,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/357","proteins":[{"symbol":"SHRM2_HUMAN","href":"/api/1.0/protein/SHRM2_HUMAN"}],"hgncRootFamilies":[]}