{"symbol":"SIGLEC5","synonyms":["OB-BP2","SIGLEC-5","CD170","OBBP2"],"name":"sialic acid binding Ig-like lectin 5","description":"This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]","ncbiEntrezGeneId":8778,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8778","proteins":[{"symbol":"SIGL5_HUMAN","href":"/api/1.0/protein/SIGL5_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"Sialic acid binding Ig-like lectins (SIGLECs)","href":"/api/1.0/gene_family/Sialic+acid+binding+Ig-like+lectins+%28SIGLECs%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}