{"symbol":"SIGLEC8","synonyms":["SAF2","SIGLEC-8","SIGLEC8L"],"name":"sialic acid binding Ig-like lectin 8","description":"Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]","ncbiEntrezGeneId":27181,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27181","proteins":[{"symbol":"SIGL8_HUMAN","href":"/api/1.0/protein/SIGL8_HUMAN"}],"hgncRootFamilies":[{"name":"Sialic acid binding Ig-like lectins (SIGLECs)","href":"/api/1.0/gene_family/Sialic+acid+binding+Ig-like+lectins+%28SIGLECs%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}