{"symbol":"SIM2","synonyms":["BHLHE15","HMC29C01","HMC13F06","SIM"],"name":"single-minded family bHLH transcription factor 2","description":"This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]","ncbiEntrezGeneId":6493,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6493","proteins":[{"symbol":"SIM2_HUMAN","href":"/api/1.0/protein/SIM2_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"}]}