{"symbol":"SIPA1","synonyms":["SPA1"],"name":"signal-induced proliferation-associated 1","description":"The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6494,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6494","proteins":[{"symbol":"SIPA1_HUMAN","href":"/api/1.0/protein/SIPA1_HUMAN"}],"hgncRootFamilies":[]}