{"symbol":"SIRPB1","synonyms":["CD172B","SIRP-BETA-1"],"name":"signal-regulatory protein beta 1","description":"The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]","ncbiEntrezGeneId":10326,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10326","proteins":[{"symbol":"SIRB1_HUMAN","href":"/api/1.0/protein/SIRB1_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Signal-regulatory proteins (SIRP)","href":"/api/1.0/gene_family/Signal-regulatory+proteins+%28SIRP%29"}]}