{"symbol":"SIRT1","synonyms":["HSIR2","SIR2L1","SIR2alpha"],"name":"sirtuin 1","description":"This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]","ncbiEntrezGeneId":23411,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23411","proteins":[{"symbol":"SIR1_HUMAN","href":"/api/1.0/protein/SIR1_HUMAN"}],"hgncRootFamilies":[]}