{"symbol":"SIRT6","synonyms":["SIR2L6"],"name":"sirtuin 6","description":"This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":51548,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51548","proteins":[{"symbol":"SIR6_HUMAN","href":"/api/1.0/protein/SIR6_HUMAN"}],"hgncRootFamilies":[]}