{"symbol":"SIVA1","synonyms":["SIVA","SIVA-1","SIVA-2","CD27BP"],"name":"SIVA1, apoptosis-inducing factor","description":"This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]","ncbiEntrezGeneId":10572,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10572","proteins":[{"symbol":"SIVA_HUMAN","href":"/api/1.0/protein/SIVA_HUMAN"}],"hgncRootFamilies":[]}