{"symbol":"SKAP1","synonyms":["SCAP1","HEL-S-81P","SKAP55"],"name":"src kinase associated phosphoprotein 1","description":"This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8631,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8631","proteins":[{"symbol":"SKAP1_HUMAN","href":"/api/1.0/protein/SKAP1_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}