{"symbol":"SLAMF6","synonyms":["SF2000","KALIB","LY108","NTBA","CD352","NTB-A","KALI"],"name":"SLAM family member 6","description":"The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]","ncbiEntrezGeneId":114836,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/114836","proteins":[{"symbol":"SLAF6_HUMAN","href":"/api/1.0/protein/SLAF6_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}