{"symbol":"SLC12A5","synonyms":["KCC2","EIG14","hKCC2","EIEE34"],"name":"solute carrier family 12 (potassium/chloride transporter), member 5","description":"K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]","ncbiEntrezGeneId":57468,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/57468","proteins":[{"symbol":"S12A5_HUMAN","href":"/api/1.0/protein/S12A5_HUMAN"}],"hgncRootFamilies":[{"name":"Solute carriers (SLC)","href":"/api/1.0/gene_family/Solute+carriers+%28SLC%29"}]}