{"symbol":"SLC7A5","synonyms":["E16","4F2LC","MPE16","HLAT1","LAT1","D16S469E"],"name":"solute carrier family 7 (amino acid transporter light chain, L system), member 5","description":"Enables L-amino acid transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in several cellular components, including apical plasma membrane; cytosol; and microvillus membrane. Part of amino acid transport complex. Implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Biomarker of esophagitis; gastrointestinal system cancer (multiple); malignant astrocytoma (multiple); and respiratory system cancer (multiple). [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":8140,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8140","proteins":[{"symbol":"LAT1_HUMAN","href":"/api/1.0/protein/LAT1_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Solute carriers (SLC)","href":"/api/1.0/gene_family/Solute+carriers+%28SLC%29"}]}