{"symbol":"SLC8A3","synonyms":["NCX3"],"name":"solute carrier family 8 (sodium/calcium exchanger), member 3","description":"This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]","ncbiEntrezGeneId":6547,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6547","proteins":[{"symbol":"NAC3_HUMAN","href":"/api/1.0/protein/NAC3_HUMAN"}],"hgncRootFamilies":[{"name":"Solute carriers (SLC)","href":"/api/1.0/gene_family/Solute+carriers+%28SLC%29"}]}