{"symbol":"SMAD7","synonyms":["CRCS3","MADH8"],"name":"SMAD family member 7","description":"The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]","ncbiEntrezGeneId":4092,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4092","proteins":[{"symbol":"SMAD7_HUMAN","href":"/api/1.0/protein/SMAD7_HUMAN"}],"hgncRootFamilies":[{"name":"SMAD family (SMAD)","href":"/api/1.0/gene_family/SMAD+family+%28SMAD%29"}]}