{"symbol":"SMC3","synonyms":["CDLS3","CSPG6","SMC3L1","BAM"],"name":"structural maintenance of chromosomes 3","description":"This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9126,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9126","proteins":[{"symbol":"SMC3_HUMAN","href":"/api/1.0/protein/SMC3_HUMAN"}],"hgncRootFamilies":[{"name":"Proteoglycans","href":"/api/1.0/gene_family/Proteoglycans"},{"name":"Structural maintenance of chromosomes proteins (SMC)","href":"/api/1.0/gene_family/Structural+maintenance+of+chromosomes+proteins+%28SMC%29"}]}