{"symbol":"SMG7","synonyms":["EST1C","SGA56M","C1ORF16"],"name":"SMG7 nonsense mediated mRNA decay factor","description":"This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":9887,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9887","proteins":[{"symbol":"SMG7_HUMAN","href":"/api/1.0/protein/SMG7_HUMAN"}],"hgncRootFamilies":[]}