{"symbol":"SMOC2","synonyms":["BA270C4A.1","MSTP117","MSTP140","BA37D8.1","DTDP1","DJ421D16.1","MST117"],"name":"SPARC related modular calcium binding 2","description":"This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":64094,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64094","proteins":[{"symbol":"SMOC2_HUMAN","href":"/api/1.0/protein/SMOC2_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}