{"symbol":"SMURF2","synonyms":[],"name":"SMAD specific E3 ubiquitin protein ligase 2","description":"Enables SMAD binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":64750,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64750","proteins":[{"symbol":"SMUF2_HUMAN","href":"/api/1.0/protein/SMUF2_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}