{"symbol":"SNIP1","synonyms":["PMRED","PML1"],"name":"Smad nuclear interacting protein 1","description":"This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":79753,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/79753","proteins":[{"symbol":"SNIP1_HUMAN","href":"/api/1.0/protein/SNIP1_HUMAN"}],"hgncRootFamilies":[]}