{"symbol":"SNURF","synonyms":[],"name":"SNRPN upstream reading frame","description":"This gene is located within the Prader-Willi Syndrome critical region on chromosome 15. Transcripts produced from this gene initiate at an imprinting center and are paternally-imprinted. These transcripts may be bicistronic and also encode SNRPN (small nuclear ribonucleoprotein polypeptide N) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. Extensive alternative splicing and promoter usage occurs in this region and the full-length nature of some of these transcripts has not been determined. Alterations in the imprinting center are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]","ncbiEntrezGeneId":8926,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8926","proteins":[{"symbol":"SNURF_HUMAN","href":"/api/1.0/protein/SNURF_HUMAN"}],"hgncRootFamilies":[]}