{"symbol":"SNW1","synonyms":["NCOA-62","SKIIP","BX42","PRPF45","FUN20","PRP45"],"name":"SNW domain containing 1","description":"This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":22938,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22938","proteins":[{"symbol":"SNW1_HUMAN","href":"/api/1.0/protein/SNW1_HUMAN"}],"hgncRootFamilies":[]}