{"symbol":"SNX1","synonyms":["VPS5","HST17379"],"name":"sorting nexin 1","description":"This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6642,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6642","proteins":[{"symbol":"SNX1_HUMAN","href":"/api/1.0/protein/SNX1_HUMAN"}],"hgncRootFamilies":[{"name":"Sorting nexins (SNX)","href":"/api/1.0/gene_family/Sorting+nexins+%28SNX%29"}]}