{"symbol":"SNX13","synonyms":["RGS-PX1"],"name":"sorting nexin 13","description":"This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":23161,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23161","proteins":[{"symbol":"SNX13_HUMAN","href":"/api/1.0/protein/SNX13_HUMAN"}],"hgncRootFamilies":[{"name":"Sorting nexins (SNX)","href":"/api/1.0/gene_family/Sorting+nexins+%28SNX%29"}]}