{"symbol":"SOCS1","synonyms":["TIP3","SSI1","JAB","SOCS-1","CISH1","SSI-1","CIS1","TIP-3"],"name":"suppressor of cytokine signaling 1","description":"This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8651,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8651","proteins":[{"symbol":"SOCS1_HUMAN","href":"/api/1.0/protein/SOCS1_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}