{"symbol":"SOCS6","synonyms":["HSPC060","CIS-4","SOCS-6","STAI4","STATI4","SOCS4","SOCS-4","SSI4","CIS4"],"name":"suppressor of cytokine signaling 6","description":"The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9306,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9306","proteins":[{"symbol":"SOCS6_HUMAN","href":"/api/1.0/protein/SOCS6_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}