{"symbol":"SOD1","synonyms":["ALS1","HOMODIMER","IPOA","SOD","HSOD1","HEL-S-44"],"name":"superoxide dismutase 1, soluble","description":"The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]","ncbiEntrezGeneId":6647,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6647","proteins":[{"symbol":"SODC_HUMAN","href":"/api/1.0/protein/SODC_HUMAN"}],"hgncRootFamilies":[]}