{"symbol":"SP1","synonyms":[],"name":"Sp1 transcription factor","description":"The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]","ncbiEntrezGeneId":6667,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6667","proteins":[{"symbol":"SP1_HUMAN","href":"/api/1.0/protein/SP1_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}