{"symbol":"SP100","synonyms":["LYSP100B"],"name":"SP100 nuclear antigen","description":"This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":6672,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6672","proteins":[{"symbol":"SP100_HUMAN","href":"/api/1.0/protein/SP100_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}