{"symbol":"SPHK2","synonyms":["SK-2","SK 2","SPK 2","SPK-2"],"name":"sphingosine kinase 2","description":"This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":56848,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56848","proteins":[{"symbol":"SPHK2_HUMAN","href":"/api/1.0/protein/SPHK2_HUMAN"}],"hgncRootFamilies":[]}