{"symbol":"SPINT2","synonyms":["DIAR3","PB","HAI2","KOP","HAI-2"],"name":"serine peptidase inhibitor, Kunitz type, 2","description":"This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":10653,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10653","proteins":[{"symbol":"SPIT2_HUMAN","href":"/api/1.0/protein/SPIT2_HUMAN"}],"hgncRootFamilies":[]}