{"symbol":"SPRED1","synonyms":["SPRED-1","NFLS","HSPRED1","PPP1R147"],"name":"sprouty-related, EVH1 domain containing 1","description":"The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":161742,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/161742","proteins":[{"symbol":"SPRE1_HUMAN","href":"/api/1.0/protein/SPRE1_HUMAN"}],"hgncRootFamilies":[{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}