{"symbol":"SPRY4","synonyms":["HH17"],"name":"sprouty homolog 4 (Drosophila)","description":"This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]","ncbiEntrezGeneId":81848,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/81848","proteins":[{"symbol":"SPY4_HUMAN","href":"/api/1.0/protein/SPY4_HUMAN"}],"hgncRootFamilies":[]}