{"symbol":"SRY","synonyms":["SRXX1","TDY","SRXY1","TDF"],"name":"sex determining region Y","description":"This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6736,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6736","proteins":[{"symbol":"SRY_HUMAN","href":"/api/1.0/protein/SRY_HUMAN"}],"hgncRootFamilies":[]}