{"symbol":"ST5","synonyms":["DENND2B","HTS1","P126"],"name":"suppression of tumorigenicity 5","description":"This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6764,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6764","proteins":[{"symbol":"ST5_HUMAN","href":"/api/1.0/protein/ST5_HUMAN"}],"hgncRootFamilies":[{"name":"DENN/MADD domain containing (DENND)","href":"/api/1.0/gene_family/DENN%24slash%24MADD+domain+containing+%28DENND%29"}]}