{"symbol":"STAM","synonyms":["STAM1","STAM-1"],"name":"signal transducing adaptor molecule (SH3 domain and ITAM motif) 1","description":"This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]","ncbiEntrezGeneId":8027,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8027","proteins":[{"symbol":"STAM1_HUMAN","href":"/api/1.0/protein/STAM1_HUMAN"}],"hgncRootFamilies":[]}