{"symbol":"STAT4","synonyms":["SLEB11"],"name":"signal transducer and activator of transcription 4","description":"The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":6775,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6775","proteins":[{"symbol":"STAT4_HUMAN","href":"/api/1.0/protein/STAT4_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}