{"symbol":"STON1","synonyms":["SBLF","SALF","STN1","STNB1"],"name":"stonin 1","description":"Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]","ncbiEntrezGeneId":11037,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11037","proteins":[{"symbol":"STON1_HUMAN","href":"/api/1.0/protein/STON1_HUMAN"}],"hgncRootFamilies":[]}