{"symbol":"STS","synonyms":["ES","ARSC1","ASC","SSDD","XLI"],"name":"steroid sulfatase (microsomal), isozyme S","description":"This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":412,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/412","proteins":[{"symbol":"STS_HUMAN","href":"/api/1.0/protein/STS_HUMAN"}],"hgncRootFamilies":[{"name":"Sulfatases (ARS)","href":"/api/1.0/gene_family/Sulfatases+%28ARS%29"}]}