{"symbol":"STX1A","synonyms":["HPC-1","STX1","P35-1","SYN1A"],"name":"syntaxin 1A (brain)","description":"This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":6804,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6804","proteins":[{"symbol":"STX1A_HUMAN","href":"/api/1.0/protein/STX1A_HUMAN"}],"hgncRootFamilies":[{"name":"Syntaxins (STX)","href":"/api/1.0/gene_family/Syntaxins+%28STX%29"}]}