{"symbol":"SULF2","synonyms":["HSULF-2"],"name":"sulfatase 2","description":"Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":55959,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55959","proteins":[{"symbol":"SULF2_HUMAN","href":"/api/1.0/protein/SULF2_HUMAN"}],"hgncRootFamilies":[{"name":"Sulfatases (ARS)","href":"/api/1.0/gene_family/Sulfatases+%28ARS%29"}]}