{"symbol":"SUN2","synonyms":["UNC84B"],"name":"Sad1 and UNC84 domain containing 2","description":"SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a \u0027bridge\u0027 across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]","ncbiEntrezGeneId":25777,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25777","proteins":[{"symbol":"SUN2_HUMAN","href":"/api/1.0/protein/SUN2_HUMAN"}],"hgncRootFamilies":[]}