{"symbol":"T","synonyms":["SAVA","TBXT","TFT"],"name":"T, brachyury homolog (mouse)","description":"The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Variation in this gene was associated with susceptibility to neural tube defects and chordoma. A mutation in this gene was found in a family with sacral agenesis with vertebral anomalies. [provided by RefSeq, Sep 2018]","ncbiEntrezGeneId":6862,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6862","proteins":[{"symbol":"BRAC_HUMAN","href":"/api/1.0/protein/BRAC_HUMAN"}],"hgncRootFamilies":[{"name":"T-boxes (TBX)","href":"/api/1.0/gene_family/T-boxes+%28TBX%29"}]}