{"symbol":"TAB3","synonyms":["MAP3K7IP3"],"name":"TGF-beta activated kinase 1/MAP3K7 binding protein 3","description":"The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":257397,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/257397","proteins":[{"symbol":"TAB3_HUMAN","href":"/api/1.0/protein/TAB3_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}