{"symbol":"TAF1C","synonyms":["SL1","TAFI95","TAFI110","MGC:39976"],"name":"TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa","description":"Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]","ncbiEntrezGeneId":9013,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9013","proteins":[{"symbol":"TAF1C_HUMAN","href":"/api/1.0/protein/TAF1C_HUMAN"}],"hgncRootFamilies":[]}