{"symbol":"TAP2","synonyms":["RING11","APT2","ABC18","PSF2","D6S217E","PSF-2","ABCB3"],"name":"transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)","description":"The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]","ncbiEntrezGeneId":6891,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6891","proteins":[{"symbol":"TAP2_HUMAN","href":"/api/1.0/protein/TAP2_HUMAN"}],"hgncRootFamilies":[{"name":"ATP binding cassette transporters (ABC)","href":"/api/1.0/gene_family/ATP+binding+cassette+transporters+%28ABC%29"}]}