{"symbol":"TCEB3","synonyms":["TCEB3A","ELOA","SIII P110"],"name":"transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)","description":"This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6924,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6924","proteins":[{"symbol":"ELOA1_HUMAN","href":"/api/1.0/protein/ELOA1_HUMAN"}],"hgncRootFamilies":[]}